ATC code C03AA03 (WHO) | ||
 | ||
AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy
category B (D if used to treat pregnancy-induced hypertension) Routes of
administration Oral (capsules, tablets, oral solution) Legal status In general: ℞ (Prescription only) Bioavailability Variably absorbed from GI tract | ||
Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.
Contents
As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body. Trichlormethiazide works by inhibiting Na+/Cl− ion reabsorption from the distal tubules of the kidneys. In addition, trichlormethiazide increases the excretion of potassium.
Mechanism
Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic. Although trichlormethiazide is used to treat
Synthesis
Trichlormethiazide is 1,1-dioxide 3,4-dihydro-3-(dichlormethyl)-6-chloro-2H-1,2,4-benzothiadiazin-7-sulfonamide.
Synonyms of this drug are esmarin, esmalorid, anatran, carvacron, intromene, sanamirone, methahydrin, naqua, triazide, and others.