Entrez 7031 | Ensembl ENSG00000160182 | |
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Aliases TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2, trefoil factor 1 External IDs MGI: 88135 HomoloGene: 2426 GeneCards: TFF1 | ||
Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene (also called pS2 gene).
Contents
Function
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
In gastric carcinoma
TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene.