Species Human Entrez 7036 | Human Mouse Ensembl ENSG00000106327 | |
 | ||
Aliases TFR2, HFE3, TFRC2, transferrin receptor 2 External IDs MGI: 1354956 HomoloGene: 2428 GeneCards: TFR2 | ||
Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
Function
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.