Trade names Tinactin MedlinePlus a682617 CAS ID 2398-96-1 Formula C19H17NOS ATC code D01AE18 (WHO) | AHFS/Drugs.com Monograph CAS Number 2398-96-1 Molar mass 307.41 g/mol DrugBank DB00525 Trade name Tinactin | |
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Synonyms 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate Melting point 110 to 111.5 °C (230.0 to 232.7 °F) | ||
Tolnaftate (INN) is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.
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Mechanism
Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase, an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal membrane) in a similar way to allylamines.
Uses
Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.
