MedlinePlus a601248 Bioavailability 0.9-1 (oral) Molar mass 192.258 g/mol | ATC code C01BB03 (WHO) Protein binding 10-20% CAS ID 41708-72-9 | |
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AHFS/Drugs.com Micromedex Detailed Consumer Information Metabolism | ||
Medical vocabulary what does tocainide mean
Tocainide (Tonocard) is a class Ib antiarrhythmic agent. It is no longer sold in the United States.
Contents
What does tocainide mean
Pharmacokinetics
Tocainide is a lidocaine analog, that does not have significant 1st pass metabolism. It is found in two enantiomers. The R isomer is 4x as potent as the S. Oral bioavailability is 0.9-1.0. In the blood tocainide is 10-20% protein bound. The Volume of distribution is 2.5-3.5 L/kg. 30-50% is excreted unchanged in the urine. The more active R-isomer is cleared faster in anephric patients or those with severe renal dysfunction. The main metabolite is the glucuronidated tocainide carbamic acid. The glucuronosyl transferase is apparently induced by rifampin. Weak inhibition of Cyp1A2 leads to a mild theophylline interaction. (Not verbatim)
References
Tocainide Wikipedia(Text) CC BY-SA