Symbol Thymidylate_kin InterPro IPR000062 Pfam structures | Pfam PF02223 PROSITE PDOC01034 PDB RCSB PDB; PDBe; PDBj | |
Thymidylate kinase (EC 2.7.4.9; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
Contents
ATP + thymidine 5'-phosphateThymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.
Subfamilies
Human proteins containing this domain
References
Thymidylate kinase Wikipedia(Text) CC BY-SA