Routes of
administration Oral, Topical, IM Biological half-life 5-6 hours Bioavailability 25% | ATC code M03BX05 (WHO) CAS Number 602-41-5 Molar mass 563.618 g/mol | |
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AHFS/Drugs.com International Drug Names Legal status In general: ℞ (Prescription only) | ||
Thiocolchicoside
Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.
Contents
Aceclofenac and thiocolchicoside carton
Side effects
Side effect of thiocolchicoside can include nausea, allergy and vasovagal reactions.
Although muscle relaxants may have the major side effect of sedation, thiocholchicoside is free from sedation effects possible due to non-interference with nicotinic receptors.
Pharmacokinetics
Thiocolchicoside is broken down in the body to a metabolite called 3-demethylthiocolchicine (also known as SL59.0955 or M2) that could damage dividing cells therefore inducing toxicity in the embryo, neoplastic changes and fertility reduction in males. Therefore, recommended oral dose should not exceed 7 days and intramuscular dose duration should not exceed 5 days. Local skin preparations are less toxic.