Two of Us may refer to:

Film and television
The Two of Us (1967 film), a French film directed by Claude Berri
The Two of Us (2015 film), a South African film directed by Ernest Nkosi
Two of Us (1987 film), a gay-themed British television film
Two of Us (2000 film), an American television drama about a fictionalized meeting between Paul McCartney and John Lennon
The Two of Us (1981 TV series), a sitcom starring Peter Cook and Mimi Kennedy
The Two of Us (1986 TV series), a British comedy starring Nicholas Lyndhurst and Janet Dibley
The Two of Us (2009 TV series) or Tayong Dalawa, a Filipino primetime drama series
Two of Us (Azu album)
Two of Us (Joseph Williams album)
Two of Us (Phil Keaggy and Mike Pachelli album)
Two of Us (Tohoshinki album)
The Two of Us (mixtape), by Chloe x Halle
The Two of Us (Sonny & Cher album)
The Two of Us (Stafford and Macrae album)
The Two of Us (Yabrough & Peoples album)
The Two of Us, by Dinah Washington with Brook Benton, 1960
The Two of Us, by Nancy Wilson with Ramsey Lewis 1984 pop #144, RnB #42
"Two of Us" (song), by The Beatles, 1969
"Two of Us", by Ayumi Hamasaki, a B-side of the single "Depend on You", 1998
"The Two of Us", by Jackie Trent and Tony Hatch, 1967
"The Two of Us", by 'N Sync from Celebrity, 2001
"Two of Us", by Supertramp from Crisis? What Crisis?, 1975
"The 2 of Us", by Suede from Dog Man Star, 1994
"The Two of Us", by Chae Yeon, 2004
The Two of Us (play), a 1970 play by Michael Frayn
The Two of Us: My Life with John Thaw, a 2004 biography by Sheila Hancock