In Bystrica, Slovakia in 1944, near the end of World War II, an Allied bombing raid causes a tiny girl to pray for deliverance.
In Chicago, in 1979, Father Frank Shore (Ed Harris) is a priest, now a Postulator, who investigates claims of miracles for the Vatican performed by a devout woman whose death caused a statue of the Virgin Mary to bleed upon and cure a girl with terminal lupus. Now the woman has been nominated for sainthood.
Having never encountered a genuine miracle, he is known as the "Miracle Killer" for his track record for debunking false claims of miracles. Father Frank is suffering a crisis of faith when he is sent to investigate the miracles of a woman, the late Helen O'Regan who has been nominated for sainthood, and winds up becoming the greatest advocate for her canonization.
Father Frank uncovers a series of extraordinary events but the most extraordinary thing of all may be the "saint's" very earthly daughter, Roxane (Anne Heche). Roxane is a non-believer who cannot forgive her otherwise selfless mother for abandoning her at the age of 16.
Ed Harris as Father Frank Shore
Anne Heche as Roxanne
Armin Mueller-Stahl as Werner
Michael Rispoli as John Leone
Charles Haid as Bishop Cahill
Barbara Sukowa as Helen
The soundtrack to The Third Miracle was released on December 14, 1999.