The Spy Dogs are a secret organization of dogs that are dedicated to protecting their world.
Characters
All animals are intelligent enough to walk on two legs and talk. The first season of The Secret Files of the Spy Dogs used traditional cel animation, but the second season used the digital ink and paint process.
Main operatives
Dog Zero (voiced by Adam West) - A dog of an unknown breed who is the Leader of the Spy Dogs. Although never seen, Dog Zero appears to be a bloodhound.
Ralph (voiced by Micky Dolenz) - A mutt from America who is a high-ranking Spy Dog. Ralph is the leader of the group. He is very sensible and cares about other people's feelings. His personality is somewhat similar to Ryder from Paw Patrol. Ralph appears to be a Labrador Retriever/Dalmatian mix. He has a brother named Mange, who is a Chesapeake Bay Retriever.
Mitzy (voiced by Mary Kay Bergman) - A pink terrier from America who is a high-ranking Spy Dog. She is very skilled at martial arts. Mitzy appears to be a Yorkshire Terrier.
Scribble (voiced by Micky Dolenz) - A mutt from America who is a Spy Dog-in-Training. He is the comic relief of the group and is known to eat anything. Scribble appears to be a Beagle mix. His clumsy personality is similar to Marshall from Paw Patrol.
Angus (voiced by Jim Ward) - A Scottish Terrier from Scotland who is the technological genius of the Spy Dogs. He is the show's plucky comic relief, next to Scribble. He has a mother who is also from Scotland. He is somewhat similar to Rocky from Paw Patrol.
Von Rabie (voiced by Jim Cummings) - A dog of unknown breed (somewhere around Pit Bull, Boxer, Rottweiler and Doberman Pinscher) from America (originally from Australia) who is an operative of the Spy Dogs. He is the genius bruiser of the group. He is somewhat similar to Rubble from Paw Patrol.
Stahl (voiced by Michael Donovan) - A German Shepherd probably from Germany who is an operative and paranormal specialist. He is very brave and fearless.
Noodle (voiced by Dee Bradley Baker) A Poodle/Bichon Frise mix from France who likes to cook. He has a tendency to worry sometimes.
B.A.R.K. Squad - S.W.A.T. or Marine dogs. They always wear blue goggles, helmets and waistcoats.
Furry (voiced by Billy West) - A Doberman Pinscher who is the leader of the B.A.R.K. Squad.
Erin (voiced by Tress MacNeille in a Scottish an Irish accent) - An Irish Setter from Ireland. Ralph has a crush on her.
Kelly Jill and Bree (voiced by Grey DeLisle) - Twin sister Poodles from France.
Sir William (voiced by Jess Harnell) - An English Mastiff/Bulldog mix from England who is very intelligent. He is often careful and overprotective at times.
Humans
Gordon - Ralph's owner.
Arty (voiced by Mary Kay Bergman) - Scribble's owner.
Arty's Mom (voiced by Kath Soucie) - The unnamed mother of Arty.
Kerry - Mitzy's owner.
Captain Earwig / Virgil (voiced by Tom Kenny) - A fake superhero.
Frank's Owner (voiced by Estelle Harris) - The unnamed owner of Frank.
Villains
Catastrophe (voiced by Jim Cummings) - The nemesis of the Spy Dogs organization who serves as the primary antagonist of the series. He is a cat with prosthetic mechanical tail which he wore because his natural one was bitten off by a dog or lost in an accident in a rocking chair testing facility. He tried to take over the world with an army of mummy cats and Bastet. His metal tail suggests he is a parody of Dr. No, while he is sometimes seen stroking a mouse similar to Ernst Stavro Blofeld's white cat.
Maws - Catastrophe's assistant with big teeth. He is a spoof of Jaws.
Baron Bone (voiced by Clancy Brown) - A human who attempted to corner the market in beef by luring all the cows in the world with a giant ball of cud.
Miss Tenderloin (voiced by Tress MacNeille) - Baron Bone's female servant.
Colosatron - A computer that wanted to take over the world. Its name and goal are taken from the film Colossus: The Forbin Project.
D'Cell (voiced by Eddie Deezen) - A human who tried to steal every new gadget in the world so he would be on the cutting edge of technology.
Ernest Anyway - A hunter who successfully captured Bigfoot, Mokele-mbembe, Yeti, and his mother (Ernest's comment about it was "Don't ask"). He tried to capture the Loch Ness Monster (which turned out to be an elongated dachshund named Nessie) only to be thwarted by Ralph and Erin. His name is a parody of writer Ernest Hemingway.
Ernst Stavro Blowfish (voiced by Ben Stein) - He took control of all the fast food restaurants in the world just because he thinks he is evil. Named after Ernst Stavro Blofeld.
Mistress Pavlov (voiced by Wendie Malick) - She tried to use her hypnotic powers to have the owners of dogs do her bidding. A joke on the Pavlov's Dog psychology experiment.
Oatz Couture (voiced by Ami Dolenz) - She created clothes for dogs that were provoking diseases.
Porkzilla (vocal effects provided by Dee Bradley Baker) - He is not really evil. After he drank a special potion made by two girls on a turnip farm to grow bigger, he became huge and went to the city to eat. Porkzilla is a spoof of Godzilla.
Witch Doctors - A quartet of witch doctors in suits that work as Spin Doctors at the Ferret Network. After Ralph and Stahl expose their plans to hypnotize the TV viewers, they are fired by the Ferret Network's CEO.
Space Slugs (voiced by Maurice LaMarche and Billy West) - They tried to bury the world in slime to recreate their home world which was destroyed. Also tried to mutate the children of the world into Space Slugs by tainting lunchroom food in schools.
The Flea Nation (voiced by Jim Cummings and Billy West) - A race of fleas.
Granny Larceny (voiced by Tress MacNeille) - An old lady criminal who uses her babies to commit crimes.
Pookie, Wookums, and Coochy - Granny Larceny's grand-babies who are programmed to commit crimes. Pookie is a master of the rattle-chuks. Wookums is a master of diaper-fu. Coochy has the ability of sticky drool.
Al Catraz (voiced by Jeff Bennett) - The strict owner of the dog kennel where Ralph was dropped off while his owners were going on vacation. Al was displeased that his father had his dog inherit his fortune instead of Al.
Technology
Dog tags - communicators
Hydrant - hydrant samurai
Humanesks - androids large enough to be piloted by one or two spydogs, depending on model. The slimmer models are for one spydog, and the more obese models carry a co-pilot.
Pet Store Plane - planes. Usually used to transport cargo.
Toilets - invented as water bowls and communication devices
Prop Designers: Marc J. Ratner, Ron Harris, Shannon Eric Denton
Layout Designers: Ricardo Abrines, Pat R. Agnasin
Storyboard Supervisor & Director: Dave Simons
Storyboards: Tate Roman Arambula, Dave Simons, John Conning, Bob Curtis, Bill Dubay, Bob Fuentes, Mike Hedrick, Rick Hoberg, Brian Hogan, Don Jurwich, Marty Murphy, Tom Nesbitt, Norm Quebedeau, Scott Shaw, Keith Tucker, Jim Benton
Storyboard Revisionist: Lothell Jones
Color Stylist: Jo Meugniot
Painted Backgrounds: Kelly Akins
Animation Timing Director: Karen Peterson
Supervising Director: Philip A. Reynolds
Timing Directors: Dora Case, Mark Glamack, Louie Kachivas, Gwen Wetzler
Track Reader: Laure A. Wetzler
Lip Sync: Erik Jan Peterson
Direction Assistant: Robert Nadsady
Animation Checker: Joe Dempsey
Casting & Voice Director: Jamie Simone
Talent Coordinator: Gustavo A. Pablik
Dialogue Recordists: David W. Barr, Kevin Newson
Featured Voices: Micky Dolenz, Adam West, Mary Kay Bergman, Jim Cummings, Michael Donovan, Jess Harnell, Charity James, Maurice LaMarche, Tress MacNeille, Jim Ward, Billy West
Prop Design: John Fang, Marc J. Ratner, Dave Rodriguez
Layout Designers: Ricardo Abrines, Pat R. Agnasin
Storyboard Supervisor/Director: Dave Simons
Storyboards: Patrick Archibald, Jim Benton, Cullen Blaine, Mike Hedrick, Rick Hoberg, Brian Hogan, Lothell Jones, Dan Kubat, J.C. Ponce, Sarge, TV Schafrati, Marc, Schirmeister, Scott Shawi, Dave Simons, Marcus Williams
Storyboard Revisionist: James Cross, Ken Johnson, Lothell Jones
Color Stylist: Pam Gibson
Painted Backgrounds: Kelly Akins, Stephanie Pyren-Fortel
Featured Voices: Micky Dolenz, Adam West, Mary Kay Bergman, Jim Cummings, Michael Donovan, Jess Harnell, Charity James, Maurice LaMarche, Tress MacNeille, Jim Ward, Billy West
Guest Voices: Dee Baker, Jeff Bennett, Rodger Bumpass, Tifanie Christun, Cameron Clarke, Jen Darling, Grey DeLisle, Soleil Moon Frye, Brian George, Barbara Goodson, Estelle Harris, Nick Jameson, John Kassir, Tom Kenny, David McDermott, Tony Pope, Dwight Schultz, Susan Silo, Kath Soucie
Executive in Charge of Post Production: Clive H. Mizumoto
Director of Sound Operations: Xavier Garcia
Re-Recording Mixers: Mark Ettel, T.A. Moore Jr.
Dialogue Recordist: Kevin Newson
Supervising Dialogue Director: Michael Garcia
Dialogue Editors: David Barr, John Garcia, Brian Lang
Sound Designer/Supervising Sound Effects Editor: Keith Dickens
Sound Effects Editors: Brian Densmore, Keith Dickens
Foley Artists: Susan B. Lewis, Kalea L. Morton
Audio Assistants: B.C. Celello, Don Sexton, Bryan Stewart
Music by: Shuki Levy, Kussa Mahchi
Music Produced by: Glenn Scott Lacey, Jeremy Sweet, Dori Amarilio
Executive in Charge of Music: Ron Kenan
Music Supervisor: Andrew R. Muson
Music Editors: Liz Magro, Ryan Yerdon
Sound Engineers: John Sperger, Jimmy Di Julio, Tim Gosselin, Al Lay