Entrez 56302 | Ensembl n/a | |
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Aliases TRPV5, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5 External IDs MGI: 2429764 HomoloGene: 10520 GeneCards: TRPV5 |
Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.
Contents
TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss.
Function
This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
Interactions
TRPV5 has been shown to interact with S100A10.