Entrez 7205 | Ensembl ENSG00000087077 | |
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Aliases TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6 External IDs MGI: 1343458 HomoloGene: 37757 GeneCards: TRIP6 | ||
Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.
Contents
Function
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Interactions
TRIP6 has been shown to interact with LPAR2, BCAR1 and HOXA9.
References
TRIP6 Wikipedia(Text) CC BY-SA