Entrez 57761 | Ensembl ENSG00000101255 | |
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Aliases TRIB3, C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3 External IDs MGI: 1345675 HomoloGene: 10902 GeneCards: TRIB3 | ||
Function
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target
Interactions
TRIB3 has been shown to interact with:
References
TRIB3 Wikipedia(Text) CC BY-SA