Entrez 6477 | Ensembl ENSG00000196470 | |
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Aliases SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1 External IDs MGI: 108064 HomoloGene: 20654 GeneCards: SIAH1 |
Function
This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Interactions
SIAH1 has been shown to interact with:
References
SIAH1 Wikipedia(Text) CC BY-SA