Supriya Ghosh (Editor)

SIAH1

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Species
  
Entrez
  
6477

Human
  
Ensembl
  
ENSG00000196470

SIAH1

Aliases
  
SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1

External IDs
  
MGI: 108064 HomoloGene: 20654 GeneCards: SIAH1

E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene.

Contents

Function

This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Interactions

SIAH1 has been shown to interact with:

References

SIAH1 Wikipedia


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