Species Human Entrez 11277 | Human Mouse Ensembl ENSG00000213689 | |
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Aliases TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1 External IDs MGI: 1328317 HomoloGene: 7982 GeneCards: TREX1 | ||
Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.
Contents
Function
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy), and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.
clinical relevance
TREX1 helps HIV‑1 to evade cytosolic sensing by degrading viral cDNA in the cytoplasm
References
TREX1 Wikipedia(Text) CC BY-SA