Entrez 7158 | Ensembl ENSG00000067369 | |
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External IDs MGI: 1351320 HomoloGene: 4137 GeneCards: TP53BP1 | ||
Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.
Contents
Clinical significance
53BP1 is underexpressed in most cases of triple-negative breast cancer.
DNA repair
DNA double-strand breaks (DSBs) are cytotoxic damages that can be repaired either by the homologous recombinational repair (HR) pathway or by the non-homologous end-joining (NHEJ) pathway. NHEJ, although faster than HR, is less accurate. The early divergent step between the two pathways is end resection, and this step is regulated by numerous factors. In particular, BRCA1 and 53BP1 play a role in determining the balance between the two pathways. 53BP1 restricts resection and promotes NHEJ.
Interactions
53BP1 has been shown to physically interact with: