Entrez 7046 | Ensembl ENSG00000106799 | |
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Aliases TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1 External IDs MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1 | ||
Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene.
Contents
Function
The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the TGF-β signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys–Dietz aortic aneurysm syndrome (LDS, LDAS).
Interactions
TGF beta receptor 1 has been shown to interact with:
Inhibitors
References
TGF beta receptor 1 Wikipedia(Text) CC BY-SA