Aliases TBX6, SCDO5, T-box 6 Human Mouse Ensembl ENSG00000149922 | Species Human Entrez 6911 | |
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External IDs MGI: 102539 HomoloGene: 3389 GeneCards: TBX6 | ||
Gene music using protein sequence of tbx6 t box 6
T-box 6 is a protein that in humans is encoded by the TBX6 gene.
Contents
Gene music quartet using protein sequence of tbx6 t box 6
Function
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.
Tbx6 is also required for the segmentation of the paraxial mesoderm into somites, and for the normal development of the dermomyotome in zebrafish. In the absence of Tbx6, the central dermomyotome of zebrafish fails to develop.
Tbx6 functions in a gene regulatory network with mesp-b and ripply1.
References
TBX6 Wikipedia(Text) CC BY-SA