Entrez 916 | Ensembl ENSG00000198851 | |
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Aliases CD3E, IMD18, T3E, TCRE, CD3e molecule External IDs MGI: 88332 HomoloGene: 586 GeneCards: CD3E | ||
CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.
Contents
Function
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.
Clinical significance
Defects in this gene cause severe immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Interactions
T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2.