Species Human Entrez 8440 | Human Mouse Ensembl ENSG00000071051 | |
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Aliases NCK2, GRB4, NCKbeta, NCK adaptor protein 2 External IDs MGI: 1306821 HomoloGene: 20794 GeneCards: NCK2 | ||
Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.
Contents
Function
NCK belongs to family of adaptor proteins,There are two mammalian NCK genes, NCK1 and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
NCK2 has been shown to interact with: