Sterol regulatory element binding protein 2

Updated on Dec 12, 2024

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Species Human Entrez 6721		Human Mouse Ensembl ENSG00000198911

Aliases SREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2 External IDs MGI: 107585 HomoloGene: 20966 GeneCards: SREBF2

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.

Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.

Interactions

SREBF2 has been shown to interact with INSIG1 and CREB-binding protein.

References

Sterol regulatory element-binding protein 2 Wikipedia

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Contents

Function

Interactions

References