Girish Mahajan (Editor)

Steroid 17alpha monooxygenase

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EC number  1.14.99.9
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  9029-67-8
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a steroid 17alpha-monooxygenase (EC 1.14.99.9) is an enzyme that catalyzes the chemical reaction

a steroid + AH2 + O2 a 17alpha-hydroxysteroid + A + H2O

The 3 substrates of this enzyme are steroid, an electron acceptor AH2, and O2, whereas its 3 products are 17alpha-hydroxysteroid, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). Other names in common use include steroid 17alpha-hydroxylase, cytochrome P-45017alpha, cytochrome P-450 (P-45017alpha,lyase), and 17alpha-hydroxylase-C17,20 lyase. This enzyme participates in c21-steroid hormone metabolism. It has 3 cofactors: NADH, NADPH, and Heme.

References

Steroid 17alpha-monooxygenase Wikipedia


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