| 1942 – present|
| I-85 southwest of Fair Play|
US 76 / US 123 / SC 28 in Seneca
Oconee County, South Carolina
South Carolina Highway 59 (SC 59) is a 15.6-mile (25.1 km) long state highway in the northwestern part of the U.S. state of South Carolina. The highway travels in a south-north orientation from just southwest of Fair Play north and then northeast to Seneca, completely within Oconee County.
South Carolina Highway 59 Wikipedia
SC 59 begins at an interchange with Interstate 85 (I-85) just southwest of Fair Play. The route heads northeast into town, and intersects SC 182/SC 243. After leaving town, SC 59 heads northwest and turns to the northwest to intersect SC 24. The road heads on its northeast trajectory until it meets its northern terminus, an intersection with US 76/US 123 in Seneca.
Established in 1942 as a renumbering of SC 181 and part of SC 182, SC 59 traversed from the Georgia state line to Fair Play, then north to Seneca, ending at US 76/SC 13/SC 28. By 1963, SC 59 was truncated at I-85, thanks to Lake Hartwell submerging the route to Georgia; south of I-85 that was not submerged were downgraded to secondary road Lakeshore Drive (S-37-11). In 2000, SC 59 was extended northwest along West North 1st Street in Seneca, to its current northern terminus with US 76/US 123/SC 28.
Historically, there was one previous SC 59 between 1930-1942; it ran from SC 55, near Clover, to SC 58/SC 163, near Lake Wylie. In 1942, the highway was renumbered as SC 557.
The entire route is in Oconee County.