Trisha Shetty (Editor)

Sorivudine

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Trade names
  
Usevir, Brovavir

ATC code
  
none

Excretion
  
Kidney

Routes ofadministration
  
Oral

Metabolism
  
Viral thymidine kinase

Molar mass
  
349.14 g/mol

Sorivudine

Synonyms
  
BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Sorivudine (INN), is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).

Contents

Feature

  • First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
  • Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.

    • Mechanism of action

  • Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.

    • Microbiology

    Sorivudine is active against most species in the herpesvirus family.

  • Herpes simplex virus type I (HSV-1)
  • Varicella zoster virus (VZV)
  • Epstein-Barr virus (EBV)

    • Interactions

    Sorivudine interacts strongly and in some cases lethally with fluorouracil (5-FU), its prodrugs and related substances. This is based on the metabolite bromovinyluracil (BVU), which irreversibly inhibits the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. The closely related drug brivudine has the same interaction.

    References

    Sorivudine Wikipedia
    (Text) CC BY-SA


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