Siddhesh Joshi (Editor)

Simon N Powell

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Residence
  
New York, NY

Spouse
  
Naomi Joshi

Name
  
Simon Powell


Born
  
February 13, 1955 (age 69) Manchester, England (
1955-02-13
)

Nationality
  
British/Permanent Resident in the U.S.

Fields
  
Radiation Oncology and Breast Cancer Research

Institutions
  
Sloan-Kettering Institute at Memorial Sloan-Kettering Cancer Center

Alma mater
  
Oxford University, U.K. (B.A.) 1976, The University of London, U.K. (M.B.B.S.) 1981, The University of London, U.K. (Ph.D.) 1991

Education
  
University of London, University of Oxford

Simon N. Powell (born February 1955) is a British cancer researcher, residing in the United States.

Contents

Biography

Powell was born on February 13, 1955 in Manchester, England. He obtained his B.A. at the University of Oxford and initially planned to pursue a Ph.D. in neuroscience, however his career path shifted during an elective internship under Sir Michael Peckham, a professor of oncology at the Royal Marsden Hospital. Inspired by Peckham's ability to combine both clinical and basic research, Powell decided to follow his example and specialize in oncology. Powell received the Bachelor of Medicine, Bachelor of Surgery (M.B.B.S.) (the British equivalent of the M.D. degree) in 1981 from the University of London and went on to complete his Ph.D. there in 1991, holding residencies at Whittington Hospital and Hammersmith Hospital in London and a fellowship at the Royal Marsden Hospital before being recruited and settling in America.

At Harvard Medical School Powell held a fellowship in 1991, becoming an instructor in 1992 and associate professor of radiation oncology in 1998. From 2004 to 2008 he served as professor and head of Radiation therapy/radiation oncology at the Washington University School of Medicine in St. Louis.

In 2008, Powell moved to New York to become a member at Memorial Sloan-Kettering Cancer Center and a member of the Molecular Biology Program at Memorial Sloan–Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research. He was also appointed to the faculties of the Gerstner Sloan-Kettering Graduate School of Biomedical Science and Cornell Medical School, Weil Cornell Graduate School of Medical Sciences.

In addition to his academic, clinical and research work Powell was an associate editor at the International Journal of Cancer for eight years and associate editor for 5 years at the journal of Radiation Research. Powell is currently serving on the editorial board of the Journal of Cancer Biology and Therapy and has held the position since 2001. He has authored or co-authored more than 100 peer-reviewed research articles and 13 book chapters.

Career

Powell is chair of the Department of Radiation Oncology at Memorial Sloan-Kettering Cancer Center with a joint appointment in Sloan-Kettering Institute's Molecular Biology Program. He also holds the Enid A. Haupt Chair in Radiation Oncology at the Center.

Before joining Sloan-Kettering in June 2008, Powell was head of the Department of Radiation Oncology at Washington University School of Medicine in St. Louis. Previously he was with Harvard Medical School and Massachusetts General Hospital. He was clinical director of the Gillette Center for Women's Cancers, co-leader of the Harvard Breast Cancer Research Program, and leader of the DNA Repair/Radiation Biology Program.

Powell was a recipient of the European Society for Theapeutic Radiology and Oncology (E.S.T.R.O.) Varian Award in 1990. In 2008, Powell was elected Chair of the Gordon Research Conference on Radiation Oncology. He is an elected Member of the Royal College of Physicians of Edinburgh and a Fellow of the [Royal College of Radiologists of the United Kingdom. Powell is a member of the American Society for Therapeutic Radiation and Oncology, Radiation Research Society and the American Association for Cancer Research. His most recent memberships were in 2009 to the New York Academy of Sciences and the Radiological Society of North American.

Powell resides in New York City. He is board certified in radiation oncology and internal medicine (both UK), and radiation oncology (U.S.).

Selected publications

  • Powell, Simon N.; Defrank, Jeffrey S.; Connell, Paul; Eogan, Maeve; Preffer, Frederic; Dombkowski, David; Tang, Wei; Friend, Stephen (1995). "Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay". Cancer Research. 55 (8): 1643–8. PMID 7712468. 
  • Tang, W.; Tang, W; Mekeel, KL; Defrank, JS; Anné, PR; Powell, SN (1996). "High Frequency and Error-prone DNA Recombination in Ataxia Telangiectasia Cell Lines". Journal of Biological Chemistry. 271 (8): 4497–503. PMID 8626804. doi:10.1074/jbc.271.8.4497. 
  • Mekeel, Kristin L; Tang, Wei; Kachnic, Lisa A; Luo, Chen-Mei; Defrank, Jeffrey S; Powell, Simon N (1997). "Inactivation of p53 results in high rates of homologous recombination". Oncogene. 14 (15): 1847–57. PMID 9150391. doi:10.1038/sj.onc.1201143. 
  • Xia, F. (2001). "Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining". Proceedings of the National Academy of Sciences. 98 (15): 8644–9. PMC 37489 . PMID 11447276. doi:10.1073/pnas.151253498. 
  • Zhang, J; Willers, H; Feng, Z; Ghosh, JC; Kim, S; Weaver, DT; Chung, JH; Powell, SN; Xia, F (2004). "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair". Molecular and Cellular Biology. 24 (2): 708–18. PMC 343805 . PMID 14701743. doi:10.1128/MCB.24.2.708-718.2004. 
  • Romanova, Larisa Y; Willers, Henning; Blagosklonny, Mikhail V; Powell, Simon N (2004). "The interaction of p53 with replication protein a mediates suppression of homologous recombination". Oncogene. 23 (56): 9025–33. PMID 15489903. doi:10.1038/sj.onc.1207982. 
  • Litman, Rachel; Peng, Min; Jin, Zhe; Zhang, Fan; Zhang, Junran; Powell, Simon; Andreassen, Paul R.; Cantor, Sharon B. (2005). "BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ". Cancer Cell. 8 (3): 255–65. PMID 16153896. doi:10.1016/j.ccr.2005.08.004. 
  • Zhang, Junran; Ma, Zhefu; Treszezamsky, Alejandro; Powell, Simon N (2005). "MDC1 interacts with Rad51 and facilitates homologous recombination". Nature Structural & Molecular Biology. 12 (10): 902–9. PMID 16186822. doi:10.1038/nsmb991. 
  • Feng, Z.; Scott, S. P.; Bussen, W.; Sharma, G. G.; Guo, G.; Pandita, T. K.; Powell, S. N. (2010). "Rad52 inactivation is synthetically lethal with BRCA2 deficiency". Proceedings of the National Academy of Sciences. 108 (2): 686–91. PMC 3021033 . PMID 21148102. doi:10.1073/pnas.1010959107. 
  • Bott, Matthew; Brevet, Marie; Taylor, Barry S; Shimizu, Shigeki; Ito, Tatsuo; Wang, Lu; Creaney, Jenette; Lake, Richard A; et al. (2011). "The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma". Nature Genetics. 43 (7): 668–72. PMID 21642991. doi:10.1038/ng.855. 
  • Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK (July 2004). "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage". J. Biol. Chem. 279 (30): 31251–8. PMID 15159397. doi:10.1074/jbc.M405372200. 
  • Fabbro, Megan; Savage Kienan; Hobson Karen; Deans Andrew J; Powell Simon N; McArthur Grant A; Khanna Kum Kum (July 2004). "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage". J. Biol. Chem. United States. 279 (30): 31251–8. ISSN 0021-9258. PMID 15159397. doi:10.1074/jbc.M405372200. 
  • References

    Simon N. Powell Wikipedia