Type Private Headquarters Sheffield, United Kingdom | Website www.simcyp.com Parent organization Certara, L.P. | |
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Industry Pharmacokinetic modelling & simulation Products Simcyp Population-based ADME Simulator
Simcyp Paediatric
Simcyp Rat Founded 2001, Sheffield, United Kingdom CEO James Hopkins (29 Feb 2012–) Founders Geoff Tucker, Amin Rostami-Hodjegan, John Evans | ||
Simcyp
Simcyp Limited is a research-based company which provides modelling and simulation software to the pharmaceutical industry for use during drug development. Simcyp is based in Sheffield, UK.
Contents
Simcyp’s Simulators allow in silico prediction of drug absorption, distribution, metabolism and excretion (ADME) and potential drug-drug interactions.
Research and development
Simcyp’s R&D activities focus on the development of algorithms along with population and drug databases for modelling and simulation (M&S) of the absorption and disposition of drugs in patients and specific subgroups of patients across different age ranges. The Simcyp models use experimental data generated routinely during pre-clinical drug discovery and development from in vitro enzyme and cellular systems, as well as any relevant physico-chemical attributes of the drug and dosage forms. Some details of the scientific background to Simcyp approaches can be found in recent publications.
Background
Simcyp originally formed as a spin-out company from the University of Sheffield, UK. The company operates the Simcyp Consortium of pharmaceutical and biotechnology companies. The Consortium acts as a steering committee, guiding scientific research and development at Simcyp. There is also close collaboration with regulatory bodies (the U.S. Food and Drug Administration, Swedish Medical Products Agency, NAM, ECVAM) and academic centres of excellence worldwide, within the framework of the Consortium.