Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion
Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.
A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV
Members of the family include:
References
Signaling lymphocytic activation molecule Wikipedia(Text) CC BY-SA