Entrez 114836 | Ensembl ENSG00000162739 | |
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Aliases SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6 External IDs MGI: 1353620 HomoloGene: 49945 GeneCards: SLAMF6 |
SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
References
SLAMF6 Wikipedia(Text) CC BY-SA