Serine ethanolaminephosphate phosphodiesterase

In enzymology, a serine-ethanolaminephosphate phosphodiesterase (EC 3.1.4.13) is an enzyme that catalyzes the chemical reaction

serine phosphoethanolamine + H₂O ⇌ serine + ethanolamine phosphate

Thus, the two substrates of this enzyme are serine phosphoethanolamine and H₂O, whereas its two products are serine and ethanolamine phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is serine-phosphoethanolamine ethanolaminephosphohydrolase. Other names in common use include serine ethanolamine phosphodiester phosphodiesterase, and SEP diesterase. This enzyme participates in glycerophospholipid metabolism.