Symbol SRCR InterPro IPR001190 SCOP 1by2 | Pfam PF00530 PROSITE PDOC00348 SUPERFAMILY 1by2 | |
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In molecular biology, the protein domain SRCR is short for Scavenger receptor cysteine-rich domain. They are found solely in eukaryotes. These domains are present on the cell membrane and have a role in binding to specific ligands and are often found to be involved with the immune system.
Contents
Function
The function of these endocytic receptors are to mediating non-opsonic phagocytosis in response to foreign ligands. This triggers various processes of host defence and immune response.
Structure
The structure contains a six stranded beta-sheet and one alpha-helix.
Examples
The speract receptor found in egg, is a transmembrane glycoprotein. Other members of this family include the macrophage scavenger receptor type I, an enteropeptidase, and T-cell surface glycoprotein CD5.
References
Scavenger receptor cysteine-rich protein domain Wikipedia(Text) CC BY-SA