Sanfilippo is a surname. Notable people with the surname include:
Bruno Sanfilippo, musician and producerFrank Sanfilippo (born 1981), American soccer playerFred Sanfilippo, executive vice president for health affairs at Emory UniversityJasper Sanfilippo, an American businessman, also associated with the Place de la MusiqueJosé Sanfilippo (born 1935), Argentine footballerSylvester Sanfilippo, an American pediatrician who discovered the Sanfilippo syndromeTom SanFilippo, guitarist for the music group The VagrantsTony SanFilippo, musician who co-produced the album Vagabonds and Hooligans