Sanfilippo is a surname. Notable people with the surname include:
Bruno Sanfilippo, musician and producer
Frank Sanfilippo (born 1981), American soccer player
Fred Sanfilippo, executive vice president for health affairs at Emory University
Jasper Sanfilippo, an American businessman, also associated with the Place de la Musique
José Sanfilippo (born 1935), Argentine footballer
Sylvester Sanfilippo, an American pediatrician who discovered the Sanfilippo syndrome
Tom SanFilippo, guitarist for the music group The Vagrants
Tony SanFilippo, musician who co-produced the album Vagabonds and Hooligans