Citizenship American Name Samuel Karlin | Nationality Poland Role Mathematician | |

Fields mathematical sciencespopulation genetics Children Anna Karlin, Manuel Karlin, Kenneth D. Karlin Books A first course in stochastic, A second course in stochastic, Mathematical Methods and Theo, Theoretical studies on sex ratio, An Introduction to Stocha Similar People Christopher Burge, Marcus W Feldman, Anna Karlin, Salomon Bochner, Eviatar Nevo |

**Samuel Karlin** (June 8, 1924 – December 18, 2007) was an American mathematician at Stanford University in the late 20th century.

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## Biography

Karlin was born in Janów, Poland and immigrated to Chicago as a child. Raised in an Orthodox Jewish household, Karlin became an atheist in his teenage years and remained an atheist for the rest of his life.

Karlin earned his undergraduate degree from Illinois Institute of Technology; and then his doctorate in mathematics from Princeton University in 1947 (at the age of 22) under the supervision of Salomon Bochner. He was on the faculty of Caltech from 1948 to 1956, before becoming a professor of mathematics and statistics at Stanford.

Throughout his career, Karlin made fundamental contributions to the fields of mathematical economics, bioinformatics, game theory, evolutionary theory, biomolecular sequence analysis, and total positivity. He did extensive work in mathematical population genetics. In the early 1990s, Karlin and Stephen Altschul developed the Karlin-Altschul statistics, a basis for the highly used sequence similarity software program BLAST.

Karlin authored ten books and more than 450 articles. Karlin was a member of both the American Academy of Arts and Sciences and the National Academy of Sciences. He won a Lester R. Ford Award in 1973. In 1989, President George H. W. Bush bestowed Karlin the National Medal of Science "for his broad and remarkable research in mathematical analysis, probability theory and mathematical statistics, and in the application of these ideas to mathematical economics, mechanics, and population genetics."

Karlin's three children all became scientists. One of his sons, Kenneth D. Karlin, is a professor of chemistry at Johns Hopkins University and the 2009 winner of the American Chemical Society's F. Albert Cotton Award for Synthetic Chemistry. His other son, Manuel, is a physician in Portland, Oregon. His daughter, Anna R. Karlin, is a theoretical computer scientist, the Microsoft Professor of Computer Science & Engineering at the University of Washington.

## Selected publications

*Mathematical models in the social sciences, 1959: Proceedings of the first Stanford symposium*. Stanford, California: Stanford University Press. ISBN 9780804700214.

*Mathematical models in the social sciences, 1959: Proceedings of the first Stanford symposium*, Stanford mathematical studies in the social sciences, IV, Stanford, California: Stanford University Press, pp. 159–175, ISBN 9780804700214.

*Proc Natl Acad Sci USA*.

**87**(6): 2264–8. PMC 53667 . PMID 2315319. doi:10.1073/pnas.87.6.2264.

*Proc Natl Acad Sci USA*.

**90**(12): 5873–7. PMC 46825 . PMID 8390686. doi:10.1073/pnas.90.12.5873.