Supriya Ghosh (Editor)

Saccharopine

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3DMet
  
B01246

Formula
  
C11H20N2O6

Related compounds
  
Palmitoylethanolamide

Molar mass
  
276.2863 g/mol

Saccharopine httpsuploadwikimediaorgwikipediacommons22

Related alkanoic acids
  
4-(γ-Glutamylamino)butanoic acid Hypusine

What does saccharopine mean


Saccharopine is an intermediate in the metabolism of amino acid lysine. It is a precursor of lysine in the alpha-aminoadipate pathway which occurs in a few lower fungi, the higher fungi, and euglenids. In mammals and higher plants saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate.

Contents

Medical vocabulary what does saccharopine dehydrogenases mean


Reaction

The reactions involved, catalysed by saccharopine dehydrogenases, are:

lysine + alpha-ketoglutarate ⇌ saccharopine ⇌ glutamate + 2-aminoadipate 6-semialdehyde

Pathology

Saccharopine FileSaccharopinesvg Wikimedia Commons

Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation.

History

Saccharopine was first isolated in 1961 from yeasts (Saccharomyces, hence the name) by Darling and Larsen.

Saccharopine Characterization of the Two Saccharopine Dehydrogenase Isozymes of

Saccharopine Saccharopine Wikipdia

Saccharopine The saccharopine pathway for llysine degradation in plant

Saccharopine Synthesis of the Arabidopsis Bifunctional LysineKetoglutarate

Saccharopine IUCr Cloning expression purification and crystallization of

Saccharopine Section 16P Problems for Chapter 16 Chemistry LibreTexts

References

Saccharopine Wikipedia
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