Samiksha Jaiswal (Editor)

SOX4

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Aliases
  
SOX4, EVI16, SRY-box 4

Human
  
Ensembl
  
ENSG00000124766

Species
  
Entrez
  
6659

SOX4

External IDs
  
MGI: 98366 HomoloGene: 2338 GeneCards: SOX4

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

Contents

Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.

Interactions

SOX4 has been shown to interact with SDCBP.

References

SOX4 Wikipedia


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