Species Human Entrez 64754 | Human Mouse Ensembl ENSG00000185420 | |
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Aliases SMYD3, KMT3E, ZMYND1, ZNFN3A1, bA74P14.1, SET and MYND domain containing 3 External IDs MGI: 1916976 HomoloGene: 41491 GeneCards: SMYD3 | ||
SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.
Contents
Function
SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.
Model organisms
Model organisms have been used in the study of SMYD3 function. A conditional knockout mouse line, called Smyd3tm2a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.
Interactions
SMYD3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1 and POLR2A.
SMYD3 trimethylates a lysine residue on MAP3K2, which causes crosstalk into the MAP kinase signaling pathway in Ras-driven cancers.