Species Human Entrez 10746 | Human Mouse Ensembl ENSG00000169967 | |
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Aliases MAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2 External IDs MGI: 1346873 HomoloGene: 74576 GeneCards: MAP3K2 | ||
Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.
Contents
Function
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
Interactions
MAP3K2 has been shown to interact with:
References
MAP3K2 Wikipedia(Text) CC BY-SA