Species Human Entrez 84189 | Human Mouse Ensembl ENSG00000184564 | |
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Aliases SLITRK6, DFNMYP, SLIT and NTRK like family member 6 External IDs MGI: 2443198 HomoloGene: 12986 GeneCards: SLITRK6 | ||
SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.
Contents
Function
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.
Clinical significance
Mutations in SLITRK6 cause high myopia and deafness in humans and mice.
As a drug target
The protein is the target for the antibody-drug conjugate ASG-15ME which is in phase 1 clinical trials for urothelial cancer.
References
SLITRK6 Wikipedia(Text) CC BY-SA