Species Human Entrez 57630 | Human Mouse Ensembl ENSG00000154447 | |
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Aliases SH3RF1, POSH, RNF142, SH3MD2, SH3 domain containing ring finger 1 External IDs MGI: 1913066 HomoloGene: 10988 GeneCards: SH3RF1 | ||
Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.
Contents
Function
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Interactions
SH3RF1 has been shown to interact with AKT2 and MAP3K11.
References
SH3RF1 Wikipedia(Text) CC BY-SA