Puneet Varma

AKT2

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Species  Human
Entrez  208
Human  Mouse
Ensembl  ENSG00000105221
AKT2
Aliases  AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
External IDs  MGI: 104874 HomoloGene: 48773 GeneCards: AKT2

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.

Contents

Function

This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.

Clinical significance

The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.

Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initiated by the large T antigen as well as the neu oncogene.

Interactions

AKT2 has been shown to interact with:

References

AKT2 Wikipedia


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