Species Human Entrez 10603 | Human Mouse Ensembl ENSG00000160999 | |
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Aliases SH2B2, APS, SH2B adaptor protein 2 External IDs MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2 | ||
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
Contents
Function
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.
Interactions
SH2B2 has been shown to interact with TrkA and Cbl gene.
References
SH2B2 Wikipedia(Text) CC BY-SA