Samiksha Jaiswal (Editor)

SEPT2

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Species
  
Human

Entrez
  
4735

Human
  
Mouse

Ensembl
  
ENSG00000168385

SEPT2

Aliases
  
SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin 2

External IDs
  
MGI: 97298 HomoloGene: 3243 GeneCards: SEPT2

Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.

Contents

Function

SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that couples regulation of the DNA damage response to the cytoskeleton.

Interactions

SEPT2 has been shown to interact with:

  • SEPT6
  • SEPT7, and
  • SEPT9.

    • References

    SEPT2 Wikipedia
    (Text) CC BY-SA


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