Species Human Entrez 4735 | Human Mouse Ensembl ENSG00000168385 | |
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Aliases SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin 2 External IDs MGI: 97298 HomoloGene: 3243 GeneCards: SEPT2 | ||
Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.
Contents
Function
SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that couples regulation of the DNA damage response to the cytoskeleton.
Interactions
SEPT2 has been shown to interact with:
References
SEPT2 Wikipedia(Text) CC BY-SA