Harman Patil (Editor)

SECISBP2

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Species
  
Entrez
  
79048

Human
  
Ensembl
  
ENSG00000187742

SECISBP2

Aliases
  
SECISBP2, SBP2, SECIS binding protein 2

External IDs
  
MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.

Contents

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

References

SECISBP2 Wikipedia


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