Species Human Entrez 11231 | Human Mouse Ensembl ENSG00000025796 | |
 | ||
Aliases SEC63, DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator External IDs MGI: 2155302 HomoloGene: 5220 GeneCards: SEC63 | ||
Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.
Contents
Function
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Clinical significance
Mutations of this gene have been linked with autosomal dominant polycystic liver disease.