SDPR

Serum deprivation-response protein is a protein that in humans is encoded by the SDPR gene.

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.

SDPR is shown to act as a metastasis suppressor by xenograft studies utilizing breast cancer cell lines. SDPR may elicit its metastasis suppressor function by directly interacting with ERK and limiting its pro-survival role. Moreover, it is suggested that SDPR is silenced during breast cancer progression by promoter DNA methylation. Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.