Entrez 10284 | Ensembl ENSG00000150459 | |
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Aliases SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18 External IDs MGI: 1277978 HomoloGene: 4289 GeneCards: SAP18 | ||
Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.
Contents
Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. Additionally, SAP18s splice variants are implicated in apoptotic cycles.
Interactions
SAP18 has been shown to interact with
References
SAP18 Wikipedia(Text) CC BY-SA