Ruberlysin

Ruberlysin (EC 3.4.24.48, Crotalus ruber metalloendopeptidase II, hemorrhagic toxin II) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of His¹⁰-Leu, Ala¹⁴-Leu, Tyr¹⁶-Leu and Gly²³-Phe bonds in the B chain of insulin; His-Pro, Pro-Phe, and Trp-Ser of angiotensin I; and Gly-Phe of Met enkephalin

This endopeptidase is present in the venom of the red rattlesnake (Crotalus ruber ruber).