Following the break-up of the Cocteau Twins in 1998, Guthrie released his first solo record, Imperial, in 2003 on Bella Union Records. Guthrie's next release, which was co-written with Harold Budd, was the film score for Gregg Araki's Mysterious Skin. The soundtrack was released in May 2005 by Commotion and consists of 15 complete songs based on the short pieces used in the film.
In 2006, Guthrie signed a four-album solo deal with Darla Records, the first product of which was the album Continental. He subsequently released two four-track EPs, Everlasting and Waiting for Dawn.
Two more collaborations with Harold Budd (who had previously announced his musical retirement) were released simultaneously in 2007. After the Night Falls and Before the Day Breaks were both co-composed, co-produced and played with Budd. Like the soundtrack to Mysterious Skin, both albums are slow, drifting pieces primarily utilising treated guitar and piano.
Guthrie has also collaborated with singer Siobhan de Maré (formerly of Mono) as the band Violet Indiana. Their first full-length album, Roulette, was released in 2001. A second album, Russian Doll, followed in 2004. In March 2006 Guthrie reported on his weblog that the group had started work again on new material.
In May 2009, Mirrorball, an album-length collaboration between Guthrie and John Foxx was released on Metamatic Records.
A new solo album, Carousel, was released via Rocket Girl in Europe on 1 September 2009 and Darla Records on 15 September 2009. Additionally, Guthrie issued the Angel Falls EP in early 2009, and the Songs to Help My Children Sleep EP in October 2009. A further EP Sunflower Stories was released in March 2010
Guthrie's most recent releases are Emeralds (2011) and two collaboration albums with Harold Budd, Bordeaux and Winter Garden (with Eraldo Bernocchi) (both 2011).
He played guitar on the Telefon Tel Aviv track "The Sky Is Black", from The Birds EP (2012). Guthrie released Fortune, his newest full-length album on 26 November 2012.
In 2015, Guthrie and friend Mark Gardner of Ride wrote, performed and recorded an album 'Universal Road' together.
Guthrie currently tours live under the name "The Robin Guthrie Trio" consisting of himself, Steve Wheeler (on bass) & Antti Mäkinen (on drums). He currently works and lives in France with his wife Florence, their daughter Violette, and Lucy Belle, his daughter with Elizabeth Fraser.
In 1990 Guthrie produced Lush's second EP Mad Love and a few other songs scattered on various compilation albums. He went on to produce their 1992 debut album Spooky and Black Spring EP (1991) .
In 2005 Guthrie mixed the Amber Smith's third studio album entitled RePRINT which brought the band an international breakthrough.Studio albums
Universal Road (2015)