Nationality American Doctoral advisor Avery Morton | Fields Biochemistry Academic advisor Avery Morton | |
Died 26 May 2014, Seattle, Washington, United States Awards Guggenheim Fellowship for Natural Sciences, US & Canada People also search for Marvin H. Caruthers, Har Gobind Khorana, Avery Morton | ||
Robert Lewis Letsinger (July, 31, 1921 – May 26, 2014) was an American biochemist and was a professor of chemistry at Northwestern University. He was best known for his research and development of chemical synthesis of DNA.
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Life
Letsinger earned his B.S. in 1943 his Ph.D. in 1945, both at the Massachusetts Institute of Technology in Cambridge, Massachusetts. In 1946, he joined the department of chemistry at Northwestern University. He retired from teaching in 1991 as the emeritus Clare Hamilton Hall Professor.
Work
In the 1960s, Letsinger developed methods for solid phase synthesis of oligonucleotides, including the phosphoric triester method and the phosphoramidite synthesis. He thus laid the foundations for efficient automated synthesis of gene fragments and thus the rapid development of molecular biology.
Letsingers later dealt with nanotechnology and its application in DNA diagnostics. In 2000, Letsinger was one of the founders of the biotechnology company Nanosphere Inc.
Awards
Personal Life
Letsinger was married to Dorothy Thompson (1922-2010) in 1943. The couple had three children.