Rev ErbA

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.

The rev-Erb-α protein is a key regulatory component of the circadian clock. In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.