Kalpana Kalpana (Editor)

Rev ErbA beta

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Species
  
Human

Entrez
  
9975

Human
  
Mouse

Ensembl
  
ENSG00000174738

Rev-ErbA beta

Aliases
  
NR1D2, BD73, EAR-1R, RVR, nuclear receptor subfamily 1 group D member 2

External IDs
  
OMIM: 602304 MGI: 2449205 HomoloGene: 3763 GeneCards: NR1D2

Rev-ErbA beta (Rev-erbβ) also known as NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein that in humans is encoded by the NR1D2 gene.

Contents

Rev-erbβ is a member of the Rev-ErbA family of transcription factors. Rev-erbβ, like Rev-erbα, belongs to the nuclear receptor superfamily and can modulate gene expression by directly binding to their promoters.

Structure

Rev-erbβ is similar to Rev-erbα in its protein structure and function as a transcriptional repressor. The crystal structure of an unliganded Rev-erbβ ligand-binding domain (LBD) has been resolved (see figure to the right) and shows an extremely small ligand-binding pocket. However, Rev-erbβ has been shown to interact with heme, which appears important for its function.

The structure of Rev-erbβ complexed with heme (see figure to the left) shows a substantial movement of helices 1 (N-terminus ) and 11 (C-terminus ) which opens up a large binding pocket in the interior of the protein that is able to accommodate this ligand.

Function

Rev-erbβ has been implicated in the control of lipid and energy homoeostasis in skeletal muscle.

Rev-erbβ is also a circadian regulated gene; its mRNA displays rhythmic expression in vivo and in serum-synchronized cell cultures. However, it is currently unknown to what extent Rev-erbβ contributes to oscillations of the core circadian clock. However it has been shown heme suppresses hepatic gluconeogenic gene expression and glucose output through the related Rev-erbα receptor which mediates gene repression. Hence, the Rev-erbα receptor detects heme and thereby coordinates the cellular clock, glucose homeostasis, and energy metabolism.

References

Rev-ErbA beta Wikipedia


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